Gadd45a is a heterochromatin relaxer that enhances iPS cell generation
نویسندگان
چکیده
منابع مشابه
Why Believe That There Is a God?
This article presents an argument for the existence of God, showing that the evident phenomena are best explained by supposing that a God causes them. The argument is based on the inductive force of four very evident general phenomena: that there is a physical Universe; that it is governed by very simple natural laws; that those laws are such as to lead to the existence of human bodies; and tha...
متن کاملSmall RNA-mediated regulation of iPS cell generation
Somatic cells can be reprogrammed to an ES-like state to create induced pluripotent stem cells (iPSCs) by ectopic expression of four transcription factors, Oct4, Sox2, Klf4 and cMyc. Here, we show that cellular microRNAs (miRNAs) regulate iPSC generation. Knock-down of key microRNA pathway proteins resulted in significant decreases in reprogramming efficiency. Three miRNA clusters, miR-17∼92, m...
متن کاملCUTL1 is a target of TGF(beta) signaling that enhances cancer cell motility and invasiveness.
CUTL1, also known as CDP, Cut, or Cux-1, is a homeodomain transcriptional regulator known to be involved in development and cell cycle progression. Here we report that CUTL1 activity is associated with increased migration and invasiveness in numerous tumor cell lines, both in vitro and in vivo. Furthermore, we identify CUTL1 as a transcriptional target of transforming growth factor beta and a m...
متن کاملHeterochromatin: silence is golden
The large genomes of higher eukaryotes suggest a need for stable packaging, particularly as most of the DNA does not code for proteins, and much consists of repetitious sequences, including remnants of invading retrotransposons, transposable elements and the like. Cytological studies first demonstrated that much of the repetitous DNA is packaged in a condensed form referred to as heterochromati...
متن کاملHeterochromatin is late
Heterochromatin is late n 1953—the year that Watson and Crick published those findings " of considerable biological interest " —Howard and Pelc (1953) showed that DNA synthesis occurred in a discrete phase of the cell cycle. They had labeled DNA with radioactive phosphate. But better spatial localization of replication required a lower energy and thus more highly localized radioactive probe. Th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: EMBO reports
سال: 2016
ISSN: 1469-221X,1469-3178
DOI: 10.15252/embr.201642402